Membrane-type 1 matrix metalloproteinase is required for normal alveolar development

Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors.

Membrane type-1 matrix metalloproteinase (MT1-MMP) expressed on the tumor cell surface activates pro-MMP-2 and pro-MMP-13 to exacerbate the malignancy, suggesting its suitability as a target molecule for diagnosis by in vivo molecular imaging. Thus, we prepared radiolabeled anti-MT1-MMP monoclonal antibody (mAb) as a novel radiolabeled probe for detecting MT1-MMP in vivo and evaluated its usefu...

Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin.

Culturing DOV 13 ovarian carcinoma cells on three-dimensional collagen lattice but not on thin-layer collagen induces processing of promatrix metalloproteinase (MMP)-2 to a M(r) 62,000 form, suggesting that multivalent integrin aggregation may participate in proteinase regulation. To address the role of collagen-binding integrins in this event, we treated DOV 13 cells with soluble beta1 integri...

Membrane-type 1 matrix metalloproteinase and cell migration.

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is an integral membrane proteinase that performs processing of cell surface proteins and degradation of extracellular matrix (ECM) components. Through these proteolytic events, MT1-MMP regulates various cellular functions, including ECM turnover, promotion of cell migration and invasion, and morphogenic responses to extracellular stimuli. MT1-M...

Expression of Membrane type 1-Matrix Metalloproteinase in Laryngeal Carcinoma

Cancer cell metastasis to distant organs is the major cause of death in cancer patients. Metastasis is a multistep process, and the initial step is considered to be the invasion of surrounding stromal tissue by cancer cell. The degradation of extracellular matrix (ECM) components is essential for tumor cells to invade surrounding tissue and to form metastatic colonies in other distant organs an...

Membrane - type Matrix Metalloproteinase - 3 Regulates